Apixaban Tablets

Therapeutic Indication

Stroke prevention (AF)

Deep vein thrombosis

Pulmonary embolism

Post-surgical thromboprophylaxis

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Apixaban

Tablet

Apixaban Tablet contains the active substance apixaban and belongs to a group of medicines called anticoagulants (like warfarin) used to lower the risk of blood clots developing in patients who have a condition called atrial fibrillation (an abnormal heartbeat) as well as other risk factors for stroke. A blood clot that blocks an artery (blood vessel) is called an embolism. If the embolism occurs in the arteries of the brain it can cause a stroke. Anticoagulants slow down the time it takes for your blood to clot and reduce the risk of these events happening.
This medicine helps to prevent blood clots from forming by blocking Factor Xa, which is an important component of blood clotting.

Speciality	Cardiology \| Hematology
Tags	Anticoagulant \| Factor Xa Inhibitor
Strength	2.5 mg 5 mg
Packing Size	10 Tablets

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Mechanism

Direct selective inhibition of Factor Xa blocks thrombin formation and clot development.

Pharmacokinetics

Absorption: ~50% bioavailability
Metabolism: Liver (CYP3A4)
Elimination: Urine & feces
Half-life: ~12 hours

Side Effects

Bleeding
Anemia
Nausea

Contraindication

Active bleeding
Severe liver disease
Hypersensitivity

Interaction

NSAIDs (bleeding risk)
Other anticoagulants
CYP3A4 inhibitors (increase levels)

Warning and Precautions

Monitor bleeding
Avoid abrupt discontinuation

Dosage

As directed by the Dietician.