Calcium Citrate Malate + Calcitriol + Vitamin D3 Tablets

Mechanism

Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. Low blood levels of calcium may cause bone disease. Calcitriol is in a class of vitamins. It works by helping the body to use more of the calcium found in foods or supplements.
Calcitriol is also sometimes used to treat rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and familial hypophosphatemia (rickets or osteomalacia caused by decreased ability to break down vitamin D in the body). It is also sometimes used to increase the amount of calcium in the blood of premature (born early) babies. Vitamin D3 The most important function of vitamin D₃ is its effect on bone growth, density and structural integrity. This vitamin is needed for proper integration of calcium and phosphorous to make strong, healthy bones. Vitamin D₃ is important for the absorption of calcium and phosphorus. Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.
Calcium citrate is calcium salt of citric acid. Calcium (Ca²⁺) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation. It has been demonstrated that calcium from calcium citrate-malate (CCM), a mixture of calcium, citric acid and malic acid, is better-absorbed than calcium from calcium carbonate (CaCO₃). Calcium is used to produce the minerals contained in bones, shells and teeth through a process called biomineralisation.

Pharmacokinetics

• Calcium Absorption: Citrate Malate form ensures high bioavailability and better absorption compared to carbonate.
• Calcitriol Absorption: Rapidly absorbed; peak plasma concentration within 3–6 hours.
• Vitamin D3 Absorption: Fat‑soluble; absorbed in intestine and metabolized to calcitriol.
• Distribution: Calcium distributed to bones and teeth; Calcitriol and Vitamin D3 stored in fat and muscle.
• Excretion: Calcium via urine and feces; Vitamin D metabolites via bile; Calcitriol via urine.
• Half-life: Calcium ~hours; Vitamin D3 ~15 days; Calcitriol ~5–8 hours.

Side Effects

• Constipation
• Nausea
• Hypercalcemia (rare)
• Abdominal discomfort

Contraindication

• Hypercalcemia
• Renal calculi
• Vitamin D toxicity
• Hypersensitivity to any component

Interaction

• Thiazide diuretics (increase calcium levels)
• Digitalis (risk of arrhythmias with hypercalcemia)
• Anticonvulsants (reduce Vitamin D efficacy)

Warning and Precautions

• Use under medical supervision only
• Monitor calcium and Vitamin D levels during therapy
• Ensure adequate hydration

Dosage

As directed by the Physician.